Ondansetron and metoclopramide: a comparative analysis of effectiveness and cost in hospitalized patients with hyperemesis gravidarum

Background: Hyperemesis Gravidarum (HG) is nausea and vomiting which interfere pregnant women’s daily activities.Ondansetron (ODN) often used off label for the treatment of hyperemesis gravidarum. This study aimed to analyze theefficacy cost ondansetron versus metoclopramide (MCP), a drug that has been in standard regimen thetreatment HG. patients largest hospital Jakarta during year 2012 2016.Method: The research was conducted with cross-sectional design on respondents criteria, namely pregnantpatients hospitalized HG at Dr. Cipto Mangunkusumo Hospital from 2012-2016. Assessment clinical effectiveness wascarried out by looking day’s duration until symptoms stopped. Furthermore, analysiswas carried calculating average direct medical costs associated HG’s condition.Result: both antiemetics not statistically significant (p = 0.370). per patient withondansetron compared significantly different 0,966).Conclusion: There no difference ODN MCP hyperemesisgravidarum.